Medical uses. Oxycodone is used for managing moderate to severe acute or chronic pain when other treatments are not sufficient. It may improve quality of life in certain types of pain. It is unclear if use in chronic pain results in improved quality of life or ongoing pain relief. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Naproxen is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. Dilaudid and oxycodone are prescription opioids, a class of strong pain-relieving drugs. See how the two compare in side effects, warnings, and more. Tramadol, oxycodone, and controlled-release oxycodone are drugs used to treat moderate to severe pain. Learn how these drugs are similar and different. Ibuprofen vs Naproxen. Ibuprofen is a particular drug that falls within the category of nonsteroidal anti-inflammatory drugs or NSAIDs. Ibuprofen tends to work by creating a reduction in the secretion of hormones that initiate inflammation and associated pain in the body. Oxycodone has a risk for abuse and addiction, which can lead to overdose and death. Oxycodone may also cause severe, possibly fatal, breathing problems. To lower your risk, your doctor should have. Use of nonsteroidal anti-inflammatory drug-containing products such as naproxen; sumatriptan cause an increased risk of serious gastrointestinal adverse events including GI bleeding, ulceration, and GI perforation, which can be fatal. Naproxen, like all nonsteroidal anti-inflammatory drugs (NSAIDs), may exacerbate hypertension and congestive heart failure and may cause an increased risk of serious cardiovascular thromboembolism, myocardial infarction, and stroke, which can be fatal. OxyContin (oxycodone) is a narcotic pain reliever used to treat moderate to severe pain. Includes OxyContin side effects, interactions and indications. Naproxen, sold under the brand names Aleve and Naprosyn among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, and fever. It is taken by mouth. It is available in immediate and delayed release formulations. Onset of effects is within an hour and.